產(chǎn)品詳情

  • 產(chǎn)品名稱：rCalciseptine(CaS)

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  • 產(chǎn)品廠商：BioLeaf
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簡單介紹：
rCalciseptine(CaS)
詳情介紹：
Sequence MRICYIHKAS LPRATKTCVE NTCYKMFIRT QREYISERGC GCPTAMWPYQ TECCKGDRCN K.
Specificity Calciseptine is a specific antagonist of L-type channels1.
Characteristics Source: Dendroaspis polylepis polylepis (Black mamba snake).
Molecular formula: C304H477N91O88S11.
Disulfide bonds between Cys4-Cys23, Cys18-Cys40, Cys42-Cys53 and Cys54-Cys59.
Purity > 98 %
Molecular Weight 7167
Application Notes 100 nM-2M
Restrictions For Research Use only
Format Lyophilized
Reconstitution Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Concentration after reconstitution: Dissolving 50g in 0.698ml will provide a stock solution of 10 M.
Handling Advice Soluble in Water.
Product cited in: García, Hernández-Gallegos, Escamilla, Sánchez: "Calciseptine, a Ca2+ channel blocker, has agonist actions on L-type Ca2+ currents of frog and mammalian skeletal muscle." in: The Journal of membrane biology, Vol. 184, Issue 2, pp. 121-9, 2001 (PubMed).

Tripathy, Resch, Xu, Valdivia, Meissner: "Imperatoxin A induces subconductance states in Ca2+ release channels (ryanodine receptors) of cardiac and skeletal muscle." in: The Journal of general physiology, Vol. 111, Issue 5, pp. 679-90, 1998 (PubMed).

Teramoto, Ogata, Okabe, Kameyama, Kameyama, Watanabe, Kuriyama, Kitamura: "Effects of calciseptine on unitary barium channel currents in guinea-pig portal vein." in: Pflügers Archiv : European journal of physiology, Vol. 432, Issue 3, pp. 462-70, 1996 (PubMed).

de Weille, Schweitz, Maes, Tartar, Lazdunski: "Calciseptine, a peptide isolated from black mamba venom, is a specific blocker of the L-type calcium channel." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 6, pp. 2437-40, 1991 (PubMed).

Schweitz, Bidard, Lazdunski: "Purification and pharmacological characterization of peptide toxins from the black mamba (Dendroaspis polylepis) venom." in: Toxicon : official journal of the International Society on Toxinology, Vol. 28, Issue 7, pp. 847-56, 1990 (PubMed).