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  • 產(chǎn)品名稱：AZ-3146

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  • 產(chǎn)品廠商：Biovision
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AZ-3146
詳情介紹：
Purpose AZ 3146 is a potent and selective Mps1 (monopolar spindle 1) kinase inhibitor
Characteristics AZ 3146 is a potent and selective Mps1 (monopolar spindle 1) kinase inhibitor (IC?? = 35 nM). Shows selectivity over 46 other kinases including aurora kinase B and Cdk1. AZ 3146 overrides spindle assembly checkpoint and also interferes with chromosome alignment. It has shown to inhibit the recruitment of Mad1, 2 and centromere protein E (CENP-E) to kinetochores.
Purity ≥ 98?% by HPLC
Chemical Name 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one
Formula C??H??N?O?
Permeability Cell-permeable
Solubility DMSO(>10 mg/ml))
Molecular Weight 452.55 g/mol
CAS-No 1124329-14-1
Restrictions For Research Use only
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months