產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：Acalabrutinib

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠(chǎng)商：Biovision
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Acalabrutinib
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Purpose Acalabrutinib
Characteristics Acalabrutinib (ACP-196) is an orally available, selective irreversible inhibitor of Bruton’s tyrosine kinase (BTK) with potential antineoplastic activity. It is a second generation BTK inhibitor with improved pharmacological properties with better plasma exposure, oral absorption and shorter half-life. It prevents the activation of B-cell antigen receptor (BCR) signaling pathway, thus preventing B-cell activation and BTK mediated activation of downstream survival pathways.
Purity ≥ 98?% by HPLC
Chemical Name (S)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide; ACP-196
Formula C??H??N?O?
Permeability Cell-permeable
Solubility DMSO
Molecular Weight 465.52 g/mol
CAS-No 1420477-60-6
Restrictions For Research Use only
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months