Characteristics
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Etoposide is an antitumor agent that complexes with topoisomerase II and DNA to enhance double-strand and single-strand cleavage of DNA and reversibly inhibit religation. Blocks the cell cycle in in S-phase and G2-phase of the cell cycle, induces apoptosis in normal and tumor cell lines, inhibits synthesis of the oncoprotein Mdm2 and induces apoptosis in tumor lines that
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