產(chǎn)品詳情

  • 產(chǎn)品名稱：Caspase-2InhibitorZ-VDVAD-FMK

  • 產(chǎn)品型號：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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簡單介紹：
Caspase-2InhibitorZ-VDVAD-FMK
詳情介紹：
Purpose A caspase-4 inhibitor
Sequence Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-FMK
Characteristics PubChem CID: 44135215
A synthetic peptide that irreversibly inhibits activity of caspase-2. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Purity > 98?% by HPLC
Chemical Name Z-VDVAD-FMK, Caspase-2 Inhibitor, Z-VDVAD-fluoromethylketone
Formula C??H??FN?O??
Permeability Cell-permeable
Solubility DMSO
Molecular Weight 695.7 g/mol
Application Notes We recommend using 1000-5000X dilutions for inhibiting caspase-2 activity in Jurkat cell culture (e.g., Add 0.2-1 μL to 1 mL of culture medium). The optimal doses may vary for different cells and culture conditions.
Restrictions For Research Use only
Format Liquid
Concentration 10 mM
Handling Advice Protect from light and moisture
Storage -20 °C
Expiry Date 12 months
Supplier Images
image for Caspase-2 Inhibitor Z-VDVAD-FMK (ABIN412390) Caspase-2 Inhibitor Z-VDVAD-FMK
Product cited in: Chen, Liou, Chen, Chen, Hu, Wang, Lin: "Coenzyme Q10 rescues ethanol-induced corneal fibroblast apoptosis through the inhibition of caspase-2 activation." in: The Journal of biological chemistry, Vol. 288, Issue 17, pp. 11689-704, 2013 (PubMed).

Gillet, Dewals, Farnir, de Leval, Vanderplasschen: "Bovine herpesvirus 4 induces apoptosis of human carcinoma cell lines in vitro and in vivo." in: Cancer research, Vol. 65, Issue 20, pp. 9463-72, 2005 (PubMed).

Yen, Mar, Craciunescu, Edwards, Zeisel: "Deficiency in methionine, tryptophan, isoleucine, or choline induces apoptosis in cultured cells." in: The Journal of nutrition, Vol. 132, Issue 7, pp. 1840-7, 2002 (PubMed).