Background
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Secreted as part of the adaptive immune response by plasma B cells, immunoglobulin G constitutes 75 % of serum immunoglobulins. Immunoglobulin G binds to viruses, bacteria, as well as fungi and facilitates their destruction or neutralization via agglutination (and thereby immobilizing them), activation of the compliment cascade, and opsinization for phagocytosis. The F(ab) fragment is the portion of the antibody that binds to the antigen target. The F(ab')2 fragment results from cleavage of the antibody molecule in such a way that both F(ab)s remain connected.
Synonyms: Mouse immunoglobulin Fab, F(ab'), F(ab')2, Fragment antigen-binding
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