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Characteristics
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Calcium-chelating compounds have been used effectively for the detection of bone mineralization, growth, and morphological changes, including tetracycline derivatives, xylenol orange, alizarin, calcein, and fluorescein. These characteristics have been used to produce a near infrared (NIR) optical bone marker for small animal imaging. Using MC3T3-E1 (osteoblasts) in in vitro cell-based assays, the IRDye BoneTag shows specific binding characteristics. In vivo testing of IRDye BoneTag optical probes are effective for skeletal labeling for imaging, which is unabated several weeks post-administration.
calcium-chelating compound
Optical Probe
Upon receipt, store at -20 °C prior to reconstitution. Reconstituted product should be used immediately.
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